Chemical Constituents, Antioxidant and Cytotoxic Potential of Chloroform and Ethyl Acetate Extracts of Teucrium persicum

Background: Teucrium persicum, a well-known Iranian endemic plant, has been used to treat various diseases in traditional medicine. Objectives: This study aimed assess the antioxidant and cytotoxic effects of chloroform ethyl acetate extracts T. persicum on cancer cell lines. Methods: The total phenolic flavonoid contents, as well potential were assayed. GC-MS analysis was detect chemical constituents these two extracts. cytotoxicity lines, PC-3, SW-480, HEK-293, normal lines evaluated using MTT assay. Results: average contents found be 48 ± 0.2 25 0.4, respectively (P < 0.05). measured 34 0.6 36 mg EQ/g dried extract, calculated 2.5 0.013 3 0.0023 μg/mL, According analysis, 60 61 different bioactive compounds detected extracts, respectively. results showed that SW-480 line more sensitive than PC-3 HEK-293 cells. Conclusions: It concluded had significant properties. Taking our into account, inhibiting properties strongly supported. However, it recommended further specific detailed biochemical molecular studies should conducted order discover effective compound(s) mechanism(s) responsible for producing effects.